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About 4 percent of the total dry weight of many types of brown seaweed consists of a polysaccharide known as Fucoidan. Fucoidan is a sulfated polysaccharide that possesses a complex structure. Its chief components include a sulfuric esterified L-fucose, and the trace elements of galactose, xylose, and glucuronic acid.
Japanese researchers discovered that a polysaccharide known as Fucoidan found in kombu and other types of brown seaweed (wakame, mozuku, and hijiki), causes various types of established cancer cell lines to self-destruct. Examples of cancer cell strains where this self-destruct phenomenon was observed include human acute promyelocytic leukemia cells (HL-60 cell line), human stomach cancer cells (AGS cell line), human colon cancer cells (HCT-116 cell line), and cancer cells of the descending colon (SW-480 cell line/WiDr cell line). Moreover, this self-destruction was observed to take place without affecting normal cells. Currently, efforts are underway to clarify the precise mechanism by which this phenomenon occurs.
From ancient times (dating from the Jomon era, approximately before the 2nd Century BC onwards), brown seaweed has been a mainstay of the traditional Japanese diet. The inhabitants of Okinawa, Japan enjoy some of the highest life expectancies in Japan. Okinawans happen to have one of the highest per capita consumption rates of kombu — 1 gram per person per day. It is noteworthy that the cancer death rate in Okinawa is the lowest of all the prefectures in Japan.
The average per capita consumption rate of kombu in Japan is approximately 0.5 grams per day. Such a serving of kombu would include roughly 5 mg of Fucoidan. In vivo experiments are currently underway to determine the effects of Fucoidan within living organisms. If it is confirmed that Fucoidan can help bring about apoptosis solely in cancer cells that are multiplying at uncontrolled rates, we would then have within our reach the long-dreamed-of cancer drug — one that does its job without causing adverse side effects.
1. Hepatology Research, Volume 35, Issue 3, Pages 190-198
A. Saito, M. Yoneda, S. Yokohama, M. Okada, M. Haneda, K. Nakamura
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