World wide study finds breast cancer rates on the increase world wide.

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A University of Washington report states that the number of new cases of breast cancer has jumped dramatically worldwide, from about 640,000 in 1980 to more than 1.6 million in 2010.

During the 30 years covered by the study, breast cancer cases have increased in all parts of the world by 3.1 percent a year, the researchers found. Dr. Rafael Lozano, a professor of global health at the university’s Institute for Health Metrics and Evaluation said “what we have found is that while countries such as the United States and United Kingdom have been able to greatly lower the risk of women dying from breast cancer, through better screening and treatment, countries with fewer resources are seeing their risks go up,”

Over the same period, the number of cases of cervical cancer has crept up much more slowly and deaths from that cancer have declined, although in 2010 it still killed 200,000 women around the world. In 2010, 51 percent of new cases of breast cancer and 76 percent of the 454,000 cases of cervical cancer were in developing countries, the researchers noted.

The world rightly recognizes that no woman should die because of complications related to pregnancy and childbirth, Lozano said. “Now that we can clearly see the trends in breast and cervical cancer, they need to become a central part of the discussion when priorities are being set for women’s health programs,” he said.

The report was published in the Sept. 15 online edition of The Lancet.

For the study, Lozano and colleagues collected data from more than 300 cancer registries and cause-of-death offices in 187 countries.

“It is clear from the data that since the late 1980s, women who develop breast cancer have had a better chance of surviving because early screening is working and treatment is working,” Lozano said.

In 1980, one out of every 32 women in the United States risked dying from breast cancer. By 2010, one out of every 46 women had that risk, he added.

Personally I am agreement with Dr. Lozano that early detection is playing a huge roll in the decline of the mortality rate of those afflicted with cancer. I also believe that a large reason for this success is due to the new approach to combating the disease utilized by health care centers such as The Cancer Treatment Centers of America. Integrated Medicine!

Conventional medical practitioners are now incorporating the use of alternative therapies as adjuncts to the traditional treatments. One such adjunct is fucoidan, a substance extracted from brown seaweed which has shown therapeutic value in fighting cancers over the past few decades.

Fucoidan is one of the most studied natural substances on the planet (over 900 studies listed on pubmed.com). It has a wide range of health benefits from treating cancers to dramatically improving cardio vascular health to its anti-viral properties (proven effective against H1N1).

In fact the prestigious 2011 Commercialization of Science, Technology and Research (©-STAR) Award was given to Marinova (an Austrialian based marine bio-technologies company) for its innovative fucoidan extraction process called Maritech® which is used in the manufacturing of our Zradical™ and FucoidZ™ Youngevity® products.

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New research has found that in the route to building a better sunscreen, caffeine may be the key. Caffeine has been found to change the activity of a gene involved in the destruction of cells that have DNA damage and are therefore more likely to become cancerous.

Allan Conney of the department of chemical biology at Rutgers University tested the idea by creating genetically modified (GM) mice whose ATR genes were deficient and exposing them to ultraviolet light until they developed skin cancer. After 19 weeks of UV exposure, he found that these mice developed 69% fewer tumors than those that had fully functioning ATR genes. In addition, tumors in the GM mice developed three weeks later than in standard mice.

After 34 weeks of UV exposure, all the mice had developed tumors, mainly a type of non-melanoma cancer called squamous cell carcinoma (SCC). The results were published on Monday in the Proceedings of the National Academy of Sciences.

New Jersey Skin cancer is a common disease. According to Cancer Research UK, around 100,000 cases of non-melanoma were registered in the UK in 2008, and just under 12,000 cases of the more dangerous malignant melanoma. These cancers can be caused by over-exposure to ultraviolet light from the sun, which can damage the DNA of skin cells, leading to errors when the cells divide.

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Previous research in humans and mice suggests that B vitamins, particularly folate, play a role in the prevention of colorectal cancer. Using a mouse model of naturally occurring colorectal cancer, the USDA HNRCA scientists examined whether a mothers’ B vitamin intake impacts her offspring’s cancer risk. Mothers were fed diets containing supplemental, adequate or mildly deficient quantities of vitamins B₂, B₆, B₁₂ and folate prior to conception through weaning after which all of the offspring received the same adequate diet.

“We saw, by far, the fewest intestinal tumors in the offspring of mothers consuming the supplemented diet,” says Jimmy Crott, PhD, senior author and a scientist in the Vitamins and Carcinogenesis Laboratory at the USDA HNRCA. “Although the tumor incidence was similar between offspring of deficient and adequate mothers, 54% of tumors in the deficient offspring were advanced and had invaded surrounding tissue while only 18% of tumors in the offspring of adequate mothers displayed these aggressive properties.”

The results were published online June 9 in the journal Gut.

Crott and colleagues associated the tumor suppression seen in the offspring of supplemented mothers with a protection against disruptions to the Wnt signaling pathway, a network of genes commonly altered in colorectal cancer.

“The strongest expression of tumor-suppressing genes in the Wnt pathway was in the offspring of supplemented mothers and the weakest was in the offspring of the mildly deficient mothers,” says first author Eric Ciappio, a PhD candidate at the Friedman School of Nutrition Science and Policy at Tufts.

“We attribute these differences in gene expression to epigenetics, modifications of DNA which are sensitive to environmental factors such as diet,” Ciappio continues. “In this case, changing maternal B vitamin intake had lasting epigenetic effects in offspring and may explain the differences in tumor incidence and aggressiveness we observed.”

It remains unclear whether maternal consumption of the four B vitamins could impact tumor development in humans. “”While evidence is beginning to accumulate to suggest that maternal consumption of supplements containing folate may afford some protection against childhood cancers in offspring, we don’t yet have the ability to determine whether the same holds true for cancers that normally present in the mid to late decades of life,” explains Crott, who is also an assistant professor at the Friedman School.

Crott adds, “Aside from the known protective effect of maternal folate against neural tube defects such as spina bifida, our results suggest that mothers consuming supplemental quantities of these B vitamins may also be protecting her children against colorectal cancer.”

This study was funded by a cooperative agreement with the Agricultural Research Service (ARS) of the United States Department of Agriculture (USDA).

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Journal Reference:

1. Eric D Ciappio, Zhenhua Liu, Ryan S Brooks, Joel B Mason, Roderick T Bronson, Jimmy W Crott. Maternal B vitamin supplementation from preconception through weaning suppresses intestinal tumorigenesis in Apc1638N mouse offspring. Gut, 9 June 2011 DOI: 10.1136/gut.2011.240291

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You  probably already know Patrick Swayze succumb to cancer this week.  We can add his name to the list of notables, Farrah Fawcett. Tony Snow and Peter Jennings (to name a few) who have lost their battle with this disease over the last few years.  The sad truth is that there are some 1,500 deaths per day that are attributed  to this disease.  My question here is weather it is the cancer that is killing these people or the treatment?

While chemotherapy has prolonged lives, it is running up against limits. Lung, colon, breast and prostate cancers, the four main killers, essentially ”remain incurable by standard chemotherapy” once they have spread to other parts of the body, said Dr. Lawrence N. Shulman, chief medical officer of the Dana-Farber Cancer Institute in Boston.  More target therapies are under development however they are in the infant stages in terms of research and development.  Even if these targeted therapies do happen to show promise in the future they are still years down the road from being considered as accepted effective therapies.

We all know that chemotherapy is a drug treatment that uses powerful chemicals to kill fast-growing cells in your body. Chemotherapy is most often used to treat cancer, since cancer cells grow and multiply much more quickly than most cells in the body.  The agents (drugs) that are used (mimic immune system response) identify and attack the cells in the body that grow rapidly.  This also includes fast growing non cancerous cells such as those found in hair, bone marrow and crypt cells of the lining of the small intestine and cells lining the reproductive tract to name a few.  The destruction of the bone marrow cells may very well be an important factor in the cure being equally as detrimental as the disease.   As we know leukocytes are produced in the bone marrow and are reasonably fast growing cells (especially in times when the body perceives that it is under attack).  Among these leukocyte cells are the lymphocyte type  (B cells, T cells {CD4 & CD8} & NK {natural killer cells}) which are critical in dealing with the mechanisms of disease.  These cells are the core members of the immune systems response to cancer.  Chemotherapy subsequently leaves the body totally unprotected against any cancer cells that remain in the body after the Chemo & Radiation treatments have been given.

The effects of the chemotherapy is not seen during the onset of treatment rather in the latter stages.  Many white blood cells grow and divide rapidly to deal with an illness and have a very short life span (hours to days).  In the case of Leukocytes however, although they do tend to grow rapidly and have a much longer life span (months to years) and they do not divide rapidly.  Basically this means that the extra cells needed to fight disease must come from the production of new cells and not from (cell division) the existing cells.  It is this slow cell division combined with the severely diminishes capacity of production that is the main problem with this type of therapy.

The fact is that both chemotherapy and radiation therapy are both carcinogenic, which means that they can cause cancer.  Many times, months or years after the treatments, patients develop secondary cancers.  Chemotherapy destroys cancer cells by disrupting cell division. However, normal cells are also affected, especially if the dose is too high or if certain drugs are used. For example, etoposide is associated with an increased risk of acute leukemia compared to other chemotherapy drugs. Furthermore, secondary cancers are more frequent in patients who receive radiation therapy and chemotherapy compared to either treatment alone.

How can secondary cancers be prevented?

Define the risk of recurrence and tailor the intensity of cancer therapy: Over the past decade there has been great progress in defining risk groups for various cancers.  The importance of defining risk groups is that less treatment can be given to those who have a low risk of recurrence of cancer with standard treatments and more treatment can be given to those at high risk. Lowering the dose of treatment for low risk groups is probably the most important way to prevent secondary cancers since these cancers occur more often in intensively treated patients.

Avoid radiation therapy: Another way to decrease the incidence of second cancers is to avoid radiation therapy.  This has been successful in childhood ALL where intrathecal (into the spinal fluid) chemotherapy has been substituted for radiation therapy.  Radiation therapy is also being used less in the treatment of Hodgkin’s disease and non-Hodgkin’s lymphoma where certain groups of patients have been found to survive just as well with chemotherapy alone as with chemotherapy plus radiation therapy.

Avoid drugs with high carcinogenic potential: This is difficult to do since all chemotherapy drugs are carcinogenic.  However, etoposide is associated with a relatively high incidence of myelodysplasia and acute myeloid leukemia and in some instances other drugs could be used instead.

Again,  I can’t state this enough and will continue to pound it into you, the BEST way to prevent any illness is to unsure that your immune system if functioning at optimal levels at all times.  Your body is designed to deal with any invader on it’s own.  I agree that early detection is the key to fighting this disease.  However I also believe that if your immune system, as well as the rest of your body, is functioning properly at the cellular level the risk of getting cancer is greatly diminished.

Take quality nutritional supplements daily for optimal holistic health.

Find effective nutritional supplements that improve immune system function and take them daily!

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